Hair loss treatment

Br J Dermatol. 2010 May 25.

Intermediate hair follicles: a new more clinically relevant model for hair regrowth investigations.
Miranda BH, et al

Edited for hair loss treatment blog

Abstract
ABSTRACT Background: Alopecia ( hair loss ) causes widespread psychological distress, but is relatively poorly controlled. The development of new hair loss treatments is hampered by the lack of suitable human hair follicle models. Although intermediate and vellus hair follicles are the main clinical target for pharmacological therapy, terminal hair follicles are more frequently studied as smaller hair follicles are more difficult to obtain. Objectives: This investigation was designed to quantify in vivo morphological and in vitro behavioural differences in organ culture between matched intermediate and terminal hair follicles, in order to develop a new clinically-relevant model system. Methods: Microdissected terminal and intermediate hair follicles, from the same individuals, were analysed morphometrically (250 follicles; 5 individuals), or observed and measured over 9 days of organ culture (210 follicles; 6 individuals). Results: Intermediate hair follicles were less pigmented and smaller, penetrating less below the skin surface, with smaller fibre, connective tissue sheath, bulb and dermal papilla diameters. Intermediate hair follicle bulbs appeared 'tubular' unlike their 'bulbous' terminal follicle counterparts. In organ culture they also grew more slowly, remained in anagen longe and produced less hair fibre than terminal follicles. Conclusions: Smaller intermediate hair follicles showed major morphological differences to terminal follicles and retained significant, biologically-relevant differences in vitro in organ culture. Therefore, intermediate hair follicles offer a novel, exciting, more clinically-relevant, albeit technically difficult, model for future investigations into hair growth. This should be particularly important for developing new treatmens for hair loss.