Post details: Ameliration of ara-C Hair loss


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Ameliration of ara-C Hair loss

edited for hair loss treatment blog

Cancer Epidemiol. 2009;33:293.

The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents.
Sun B,et al
BACKGROUND: Active hexose correlated compound (AHCC)... was used to assess amelioration of alopecia (hair loss) caused by cytosine arabinoside (Ara-C).. Follicular integrity and hair growth was assessed in male and female SD neonatal rats (8 days old) treated with a single dose of Ara-C (30 mg/kg/day, i.p.) and AHCC (500 mg/kg/day, p.o.) for 7 consecutive days. The side effects of a single oral dose of 6-MP plus MTX and their amelioration by treatment with AHCC (1000 mg/kg body weight) for 28 days were assessed in male ddY mice. RESULTS: Of the Ara-C treated rats 71.4% showed severe alopecia and 28.6% showed moderate hair loss. However, the AHCC -treated Ara-C group was significantly protected from alopecia. Ara-treated rats had profound loss of hair follicles but the Ara-C plus AHCC-treated group had mild losses of follicles.snip..


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