Hair loss treatment

Br J Dermatol. 2009 Aug;161:228

Epidermal stem cells: practical perspectives and potential uses.
Abbas O, Mahalingam M.

Modified for hair loss blog

Throughout adult life, the epidermis and the hair follicle undergo a perpetual cycle of regrowth, regression and rest. Stem cells in the epidermis not only ensure the maintenance of epidermal homeostasis and hair regrowth, but also contribute to repair of the epidermis after injury. These stem cells lie within specific niches in the hair follicle and the epidermis. The availability of monoclonal antibodies that can be used on formalin-fixed paraffin-embedded tissue has greatly facilitated the use of this methodology as an adjunct to uncovering stem cell niches. In this review, we attempt to provide an overview of the potential markers available to identify and study stem cells in an effort to providing a better understanding of the pathogenesis of skin diseases including disorders of hair loss and malignancies. The potential uses of these markers in prognosis and in expanding the treatment options in several hair loss disorders will also be addressed.

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