Hair loss and hair regrowth

Mymensingh Med J. 2010;19:100

Histopathological changes in different stages of ha r loss due to alopecia areata.
Ahmed Z, et al

Hair loss due to alopecia areata is a common disorder affecting any of the hair bearing areas of the body. Most of the cases are diagnosed on the clinical ground only. Histopathological changes may help in the diagnosis in difficult cases. The present study was designed to observe the histopathologic changes accompanying hair loss in alopecia areata at different stages. Thirty consecutive patients suffering from alopecia areata were enrolled. Face to face interview was performed using a structured pre-tested questionnaire. At the initial visit, one 4mm punch scalp biopsy specimen was taken from an area of hair loss. ....Haematoxylin and eosin stains were used. Anagen hairs were decreased in all stages of hair loss due to alopecia areata. Telogen hairs increased in acute and chronic stages whereas catagen hairs increased markedly in sub-acute stage. Although miniaturized (atrophic) follicle was frequently found in chronic stage. It was absent in acute and sub-acute stages. Moderate to dense peribulbar infiltration of lymphocytes were observed in acute stage and mild to moderate infiltration in sub-acute stage. In chronic stage either no or mild infiltrations were observed. Peribulbar infiltration of eosinophils and macrophages were seen in all stages of alopecia areata. Alopecia areata can be diagnosed with some confidence, even when inflammatory infiltrate is absent, based on increased numbers of telogen hairs in the acute and chronic stages, increased miniaturized hairs in chronic stage and markedly increased catagen hairs in sub-acute stage.

edited for hair loss blog use. Key words hair regrowth hair loss hair loss treatment.

Dermatol Online J. 2010 15:3.

Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
Amor KT, et al

BACKGROUND: The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology. OBJECTIVE: To evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair loss and hair disorders. METHODS: A MEDLINE search was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss and hair regrowth. RESULTS: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood. LIMITATIONS: The review is broad and there are limited human studies available to date. CONCLUSION: Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair loss and are a potential area of further study.

hair loss, hair regrowth and hair loss treatment shampoosss and treatments

Clin Ophthalmol. 2010 Apr 26;4:349.

Bimatoprost in the treatment of eyelash hair loss.
Law SK.

Editd for hair loss treatment blog

Abstract
Eyelashes hypotrichosis is a condition indicated by an inadequate amount of eyelashes. Hypertrichosis of eyelashes, characterized by excessive eyelash hair growth, is a regular phenomenon associated with ophthalmic prostaglandin and prostamide analogs. Recently, the US Food and Drug Administration approved Latisse((R)) (bimatoprost 0.03% solution), identical to the ophthalmic solution for glaucoma treatment, for increasing eyelash hair length, thickness and darkness in patients with hypotrichosis of the eyelashes. When prostaglandin and prostamide analogs interact with the prostanoid receptors in the hair follicle, this most likely stimulates the resting follicles (telogen phase) to growing follicles (anagen phase). Prostaglandin and prostamide analogs may also prolong the anagen phase of eyelashes, leading to an increase of eyelash length. Although bimatoprost is effective in promoting increased regrowth of healthy eyelashes and adnexal hairs, its effectiveness in patients with eyelash hair loss due to alopecia areata is debatable and its protective effect is not yet studied in patients with eyelash loss secondary to radiation or chemotherapy. Bimatoprost is generally safe when applied to the base of the eyelashes at the lid margin with minimum side effects. However, other ocular or systemic side effects associated with ophthalmic prostaglandin and prostamide analogs may occur when instilled on the surface of the eye, and patients must be informed and monitored.

Br J Dermatol. 2009 Aug;161:228

Epidermal stem cells: practical perspectives and potential uses.
Abbas O, Mahalingam M.

Modified for hair loss blog

Throughout adult life, the epidermis and the hair follicle undergo a perpetual cycle of regrowth, regression and rest. Stem cells in the epidermis not only ensure the maintenance of epidermal homeostasis and hair regrowth, but also contribute to repair of the epidermis after injury. These stem cells lie within specific niches in the hair follicle and the epidermis. The availability of monoclonal antibodies that can be used on formalin-fixed paraffin-embedded tissue has greatly facilitated the use of this methodology as an adjunct to uncovering stem cell niches. In this review, we attempt to provide an overview of the potential markers available to identify and study stem cells in an effort to providing a better understanding of the pathogenesis of skin diseases including disorders of hair loss and malignancies. The potential uses of these markers in prognosis and in expanding the treatment options in several hair loss disorders will also be addressed.

Ketyword hair regrowth hair loss treatment

Indian J Plast Surg.2009;42:63.
Surgical treatment of secondary cicatricial hair loss of scalp and eyebrow
Ahmed Sabry Hassan

edited for hair loss treatment blog

Introduction: The scalp is probably the second most visible part of the human anatomy second only to the face. Aesthetic considerations are extremely important in devising any plan for the restitution of the scalp. The eyebrows are a very noticeable structure and make an essential contribution to facial beauty. Areas of hair loss may result from traumatic, thermal, radiation, neoplastic or infective process. The surgical replacement of hair has progressively become an important part of the practice of plastic surgery. Hair loss following extensive scarring of the scalp can be treated by transferring hair bearing parieto-occipital flaps if convenient or adjacent hair-bearing scalp after tissue expansion. Awaiting stem cell research in this vital field of aesthetic surgery there is no known method to create new hair, and all current techniques for hair loss restoration involve redistributing the patient's existing hair. Many techniques were used for treating hair loss surgically such as scalp reduction, hair grafting, the use of local flaps and the use of tissue expanders.

Hia rloss treatment and regrowth