Hair loss and hair regrowth

FASEB J. 1992;6:911

Interleukin 1 protects hair follicles from ARA-C-induced hair loss in vivo and in vitro.
Jimenez JJ,

ImuVert, a biologic response modifier, and interleukin 1 (IL 1) have been shown to protect the young rat from hair loss induced by ARA-C. In the present study the inhibition by ARA-C of DNA synthesis in hair follicles and the protective effect of ImuVert and IL 1 were investigated in vivo and in vitro. Both ImuVert and IL 1 were equally effective in protecting rats from ARA-C-induced hair loss. DNA synthesis in HFs isolated from ARA-C-treated animals was 10-20% of untreated controls. Follicles isolated from animals given either ImuVert or IL 1 before ARA-C exhibited normal DNA synthesis. In vitro, the incubation of normal rat HF with ARA-C resulted in 80% inhibition of thymidine uptake. .....

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