Redox Signaling

Abstract: Free radical signaling aka "Redox signaling"-- not so new:

e.g., from: Conference on Active Oxygen and Medicine, Honolulu, Hawaii, March 3-4 (1979)

"Role of Active Oxygen Species in Ocular and Neurological Diseases"

Peter H. Proctor, et al

" Electronically-activated species of oxygen such as superoxide or peroxide and their metabolic products may play a key role in the etiology of certain disorders of the eye and central nervous system. For example, in man, the chronic presence of elevated systemic levels of agents such as urate, homocysteine, or copper which can catalyze the production of such species and/or bind to melanin are often associated with on or more of four characteristic signs. These are psychotic behavior, movement disorders, deafness and pigmentary abnormalities. Likewise, the enzymes superoxide dismutase (SOD) or catalase are effective in the therapy of certain experimental lesions in animals such as high pressure oxygen toxicity, corneal alkali burns, and formalin-induced posterior segment uveitis. We suggest that active oxygen metabolites act as specific intermediary transmitter substances for a variety of biological processes including inflammation, fibrosis, and possibly, neurotransmission." (emphasis-added).

For earlier review on "Electron-transfer Factors in Psychsis and Dyskinesia". go here.

For later review on "Free Radicals and Human Disease" : go here

Antioxidant ros redox signaling drug treatment polyacetylene human diabetes free radical nitrone pbn nitroxide alcaptonuria homogentisic phenothiazine proxidant vitamin c ascorbate vitamin e deafness deaf tardive pigmentary abnormalities albino ototoxic drug aminoglycoside waardenberg cis-platinum adriamycin bleomycin messenger uric acid urate iron manganese iodide dalmatian ataxia dyskinesia psychosis schizophrenia dementia vascular stria vascularis substantia nigra midbrain basil ganglia locus ceruleus pigmented stroke reperfusion injury fenton's reaction cytochrome c nitric oxide myocardia infarction mitochondria catalase glutathione peroxidase transmission neurotransmission.inner ear lung platelet interstitial ards dad pulmonary.edema asbestosis asbestos cardiac atherosclerosis heart homocystinuria active antioxidant oxygen autoxidation.